Design of Floating Tablets Based on Hydroxypropyl Cellulose and Weakly Cross-Linked Poly(acrylic acid) for Gastroretentive Drug Delivery

Authors

  • Ulyana N. Zabolotnaya Institute of Pharmacy, Kazan State Medical University, Kazan, Russia https://orcid.org/0009-0004-8058-8007
  • Venera R. Timergalieva Institute of Pharmacy, Kazan State Medical University, Kazan, Russia
  • Shamil F. Nasibullin Institute of Pharmacy, Kazan State Medical University, Kazan, Russia
  • Rouslan I. Moustafine Institute of Pharmacy, Kazan State Medical University, Kazan, Russia https://orcid.org/0000-0002-0916-2853

DOI:

https://doi.org/10.31489/2959-0663/1-26-7

Keywords:

floating tablet, gastroretentive system, sustained release, interpolymer complexes, cellulose derivatives, hydroxypropyl cellulose, Carbopol®

Abstract

Floating or buoyant dosage forms are kind of gastroretentive delivery system specifically designed to achieve localized drug release in the upper gastrointestinal tract (GI). The aim of this study is to select a composition for creating a floating matrix system based on hydroxypropyl cellulose (HPC) and Carbopol® 71G (C71G) with an evaluating of the effect of sodium bicarbonate (Na-bicarbonate) on the complexation process, and to design a gastroretentive system for acyclovir delivering. The tablets are based on physical mixtures (PhMs) HPC/C71G 1:2; 1:1. All matrices containing sodium bicarbonate showed a flotation time of less than 3 minutes, with the exception of a 2:1 PhM with 10 mg of sodium bicarbonate. PhM HPC/C71G (1:1) was observed greater matrix erosion compared to a 1:2 ratio due to the lower C71G content. During the swelling process of the matrices, interaction of polymers occurs, which is confirmed by a spectral shift in the ATR-FTIR spectra and Tg by mDSC. The addition of sodium bicarbonate did not increase the release rate due to the effervescent effect. A slightly higher release rate was observed for matrices with a 1:1 polymer ratio, due to erosion of the soluble HPC polymer.

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Design of Floating Tablets Based on Hydroxypropyl Cellulose and Weakly Cross-Linked Poly(acrylic acid) for Gastroretentive Drug Delivery

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2026-03-10

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Zabolotnaya, U. N., Timergalieva, V. R., Nasibullin, S. F., & Moustafine, R. I. (2026). Design of Floating Tablets Based on Hydroxypropyl Cellulose and Weakly Cross-Linked Poly(acrylic acid) for Gastroretentive Drug Delivery. EURASIAN JOURNAL OF CHEMISTRY, 31(1(121), 73‒86. https://doi.org/10.31489/2959-0663/1-26-7

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Vol. 31 No. 1(121) (2026): Eurasian Journal of Chemistry

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ADVANCED POLYMERS AND NANOMATERIALS FOR DRUG DELIVERY AND OTHER BIOMEDICAL APPLICATIONS

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