Activity against SARS-CoV-2 of Various Anionic Disinfectants and Their Complexes with Hydrophobically Modified Chitosan

Authors

  • Alexander S. Ospennikov Lomonosov Moscow State University, Moscow, Russia
  • Galina V. Kornilaeva Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Russia;
  • Viktor F. Larichev Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Russia;
  • Irina T. Fedyakina Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Russia;
  • Lifeng Fu Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China
  • Zhuo Chen East China University of Science and Technology, Shanghai, China
  • Yangyang Yang East China University of Science and Technology, Shanghai, China
  • Andrey V. Shibaev Lomonosov Moscow State University, Moscow, Russia
  • Eduard V. Karamov Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Russia;
  • Ali S. Turgiev Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, Moscow, Russia;
  • Liping Duan National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China
  • William J. Liu Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
  • Olga E. Philippova Lomonosov Moscow State University, Moscow, Russia

DOI:

https://doi.org/10.31489/2959-0663/2-23-13

Keywords:

anionic disinfectants, SARS-CoV-2, chitosan, hydrophobic modification, polymer/surfactant complexes, sodium dodecyl benzene sulfonate, sodium caprylate, sodium lactate

Abstract

The aim of this work was to study virucidal activity against SARS-CoV-2 of several anionic disinfectants, which are antiseptics recommended by the U.S. Environmental Protection Agency (EPA), and to prepare their complexes with hydrophobically modified chitosan active against SARS-CoV-2. Experiments were performed using a clinical isolate of SARS-CoV-2 obtained from a patient in 2020. It was shown that sodium dodecyl benzene sulfonate (SDBS) is already active at rather small concentrations (above 2 mM), which completely deactivate the virus. In the same concentration range, sodium caprylate does not show activity; and sodium lactate is active against SARS-CoV-2 only at much higher concentrations (225 mM). The most effective disinfectant — sodium dodecylbenzene sulfonate — was used to prepare complexes with hydrophobically modified chitosan. It was found that such complexes exhibit antiviral activity at very low concentrations (1.9 mM chitosan monomer units and 0.25 mM SDBS), at which the polymer without surfactant is not active against SARS-CoV-2.

Author Biographies

Alexander S. Ospennikov, Lomonosov Moscow State University, Moscow, Russia

Department of Physics

Zhuo Chen, East China University of Science and Technology, Shanghai, China

Shanghai Key Laboratory of Chemical Biology, Shanghai key Laboratory of New Drug Design, School of Pharmacy

Yangyang Yang, East China University of Science and Technology, Shanghai, China

Shanghai Key Laboratory of Chemical Biology, Shanghai key Laboratory of New Drug Design,
School of Pharmacy

Andrey V. Shibaev, Lomonosov Moscow State University, Moscow, Russia

Department of Physics

Liping Duan, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China

NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases

William J. Liu, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China

NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention

Olga E. Philippova, Lomonosov Moscow State University, Moscow, Russia

Department of Physics

Downloads

Published

2023-06-27

How to Cite

Ospennikov, A. S., Kornilaeva, G. V., Larichev, V. F., Fedyakina, I. T., Fu, L., Chen, Z., … Philippova, O. E. (2023). Activity against SARS-CoV-2 of Various Anionic Disinfectants and Their Complexes with Hydrophobically Modified Chitosan. EURASIAN JOURNAL OF CHEMISTRY, 28(2 (110). https://doi.org/10.31489/2959-0663/2-23-13